| abstract |
IT REFERS TO A COMPOUND OF FORMULA I, WHERE R1 AND R2 ARE EACH H, C1-C5 ALKYL LINEAR OR NON-LINEAR, BRANCHED OR NOT; R3 IS CC-Ra; Ra IS H, C1-C8 ALKYL, C2-C8 ALKENYL, C3-C10 CYCLOALKYL, AMONG OTHERS; R4 IS H, METHYL, ETHYL, C1-C3 ALKYL PARTIALLY OR FULLY FLUORATED; A IS AROMATIC RING, MONO OR BICYCLIC, CARBOCYCLIC OR HETEROCICLIC, OPTIONALLY MONO OR POLY, SUBSTITUTED WITH C1-C8 ALKYL, C2-C8 ALKENYL, C1-C6 PERFLUOROALKYL, AMONG OTHERS; B IS CARBONYL, CH2. PREFERRED COMPOUNDS ARE: (-) - 6- {2- [2- (2,3- (METHYLEDIOXY) PHENYL) -2-METHYLPROPYL] -2-HYDROXY-OCT-3-INAOYL} -4-METHYL-2,3 -BENZOXAZIN-1-ONA; 6- {2- [2- (2,3-DIHYDRO-7-BENZOFURANIL) -2-METHYLPROPYL] -2-HYDROXY-3-OCTINYLAMINO} -4-METHYL-2,3-BENZOXAZIN-1-ONA; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE NON-STEROID MODULATORS OF PROGESTERONE RECEPTOR |