http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20070114-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
filingDate | 2006-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb54c80355b2505f72019786ff33d94c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20689c078f2b4c0f3ec855069b1b8654 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4acba840230dbd432d0eec450bf3c225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_462fd0acd11a7ae780460eeaec4ffff6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d75a6926776367f67f610bf7cd4e28a0 |
publicationDate | 2007-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PE-20070114-A1 |
titleOfInvention | TUBULIN INHIBITOR AND PROCESS FOR ITS PREPARATION |
abstract | REFERS TO THE HEMIFUMARATE COMPOUND OF 6-CHLORO-5- {2,6-DIFLUORO-4- [3- (METHYLAMINO) PROPOXI] PHENYL} -2-PIRAZIN-2-IL-N - [(1S) -2.2 , 2-TRIFLUORO-1-METHYLETHYL] PYRIMIDIN-4-AMINE AND ITS PREPARATION PROCEDURE WHICH CONSISTS OF: A) REACTING A PIRAZINE-2-CARBONITRILE IN A BASE IN AN ALCOHOL AND TREATING WITH AN AMMONIUM SALT OF AN INORGANIC ACID TO GIVE A SALT OF INORGANIC PIRAZINE-2-CARBOXIAMIDINE ACID (A); B) REACT (A) WITH AN ESTER OF MALONIC ACID OF FORMULA I, WHERE R1 AND R2 ARE EACH C1-C3 ALKYL IN AN APROTICAL SOLVENT IN THE PRESENCE OF A BASE AND ACIDIFY TO OBTAIN 2-PIRAZIN-2-IL-5 - (2,4,6-TRIFLUORO-PHENYL) -PYRIMIDINE-4,6-DIOL (B); C) CHLORINATING (B) WITH PHOSPHORUS OXYCHLORIDE AS A CHLORINATING REAGENT IN THE PRESENCE OF A BASE AMINE IN AN APROTICAL SOLVENT TO GIVE 4,6-DICHLORO-2-PIRAZIN-2-IL-5- (2,4,6-TRIFLUORO- PHENYL) -PYRIMIDINE (C); D) REACT (C) WITH (S) -2,2,2-TRIFLUORO-1-METHYL-ETHYLAMINE IN AN APROTICAL SOLVENT TO GIVE 6-CHLORO-2-PIRAZIN-2-IL-N - [(1S) - 2,2,2-TRIFLUORO-1-METHYLETHYL] -5- (2,4,6-TRIFLUOROPHENYL) PYRIMIDIN-4-AMINE (D); E) REACT 3-METHYLAMINE-PROPAN-1-OL WITH BASED BEN AN APROTIC SOLVENT AND ADD (D) TO GIVE 6-CHLORINE-5- {2,6-DIFLUORO-4- [3- (METHYLAMINE) PROPOXI] PHENYL} -2-IL-N - [(1S) -2,2,2-TRIFLUORO-1-METHYLETHYL] PYRIMIDIN-4-AMINE (E); F) REACT (E) IN AN APROTIC SOLVENT WITH FUMARIC ACID IN AN ALCOHOL TO OBTAIN SAID HEMIFUMARATE, WHICH IS A USEFUL INHIBITOR OF TUBULIN IN THE TREATMENT OF CANCER |
priorityDate | 2005-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.