abstract |
REFERS TO COMPOUNDS DERIVED FROM PIRAZOLE OF FORMULA (I) WHERE R1 IS H, HALOGEN, ALKYL (C1-C6), ALCOXY (C1-C6); R2 IS HALOGEN, (C1-C6) ALKYL, (C1-C6) ALCOXY, OR A AZIDO GROUP; R3 IS HALOGEN, HYDROXYL, ALKYL (C1-C6), AMONG OTHERS; R4 AND R5 ARE INDEPENDENTLY H, ALKYL (C1-C6), ALKENYL (C2-C6), AMONG OTHERS; Q IS ARYLUS OR HETEROAROMATIC. THE PREFERRED ARE: (PYRIDIN-3-ILMETHYL) -AMIDE OF ACID 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINO) -1H-PIRAZOL-3-CARBOXILICO, (PYRIDIN-3-ILMETIL) -AMIDE DICHLORO-ACIDO 5- (2-CHLORO-4,5-DIFLUORO-BENZOYLAMINE) -1H-PYRAZOL-3-CARBOXYL, (PYRIDIN-3-ILMETHYL) -AMIDE-ACID HYDROCHLORIDE 5- (2-CHLORO-4,5-DIFLUORO- BENZOYLAMINE) -1H-PIRAZOL-3-CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS HAVE INHIBITORY ACTIVITY OF HEPATIC GLUCOGEN PHOSPHORYLASE AND THAT IS USEFUL AS A THERAPEUTIC OR PROPHYLACTIC AGENT TO FIGHT DIABETES |