| abstract |
REFERS TO COMPOUNDS OF 5H-BENZOCYCLOHEPTENES OF FORMULA (I) WHERE R1 AND R2 ARE INDEPENDENTLY H, HYDROXY, HALOGEN, ALKYL (C1-C10), CYANE, -CF3, AMONG OTHERS; R11 AND R12 ARE H; R3 IS ALKYL (C1-C10), OPTIONALLY SUBSTITUTED PHENYL, MONO- OR BICYCLIC HETEROARYL, CONTAINING 1 TO 3 N ATOMS, AND / OOUS, OPTIONALLY SUBSTITUTED WITH CETUS, ALKYL (C1-C5), BETWEEN OTHERS , ISOINDOLYL, DIHYDROISOINDOLYL, AMONG OTHERS; A IS -CR6R7-CH2- OR -CH2-CR6R7- WHERE R6 AND R7 ARE H, METHYL, ETHYL OR TOGETHER WITH THE CARBON OF 5H-BENZOCICLOHEPTENO IS A CYCLOALKYL RING (C3-C6); D IS -CR4R5-CH2- OR -CH2-CR4R5- WHERE R4 IS HYDROXY, AMONG OTHERS AND R5 IS ALKYL (C1-C5) OPTIONALLY FLUORATED, CYCLOALKYL (C3-C7), AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 1-BROMO-6,7,8,9-TETRAHYDRO-5 - [(1H-INDAZOL-4-IL) AMINO] -8,8-DIMETHYL-6- (TRIFLUOROMETIL) -5H-BENZOCICLOHEPTEN-6 -OL, 4 - {[1-BROMO-6,7,8,9-TETRAHYDRO-6-HYDROXY-8,8-DIMETHYL-6- (TRIFLUORomethyl) -5H-BENZOCICLOHEPTEN-5-IL] AMINO} -1, 3-DIHYDRO-2H-INDOL-2-ONA, 2-CHLORO-6,7,8,9-TETRAHYDRO-5- (1H-INDAZOL-4-ILAMINO) -8,8-DIMETHYL-6- (TRIFLUOROMETHYL) - 5H-BENZOCICLOHEPTEN-6-OL, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS INHIBIT THE SECRETION OF CYTOKINE IL-8 CAUSED BY LIPOPOLYSACCHARIDES (LPS), BEING USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES SUCH AS BRONCHIAL ASTHMA, RHEUMATOID ARTHRITIS, ATOPIC DERMATITIS, PSORIASIS |