abstract |
6-DIMETHYLAMINOMETHYL-1- (3-METOXYPHENYL) -1,3-DIHYDROXYCLYCLOHEXANE COMPOUNDS OF FORMULA (I), WHERE R1 IS OH, R2 IS OH AND R3 IS H; OR R3 IS OH AND R2 IS H; AND R4 IS CH3; WHICH ARE PRESENTED IN THE FORM OF THEIR PHOSPHORIC ACID SALTS, PREFERENTIALLY DIPHOSPHORIC AND / OR ORTHOPHOSPHORIC; THE ORTHOPHOSPHATE SALT OF THE RACEMIC COMPOUND (1RS, 3RS, 6RS) -6-DIMETHYLAMINOMETHYL-1- (3-METOXIFENIL) -CLICLOHEXAN-1,3-DIOL being preferred. A PROCESS FOR THE PREPARATION OF SUCH SALTS WHICH INCLUDES IN REACTING THE HYDROCHLORIDE OF THE COMPOUND (I) OR ITS FREE BASE, IN PHOSPHORIC ACID IN A MOLAR RATIO OF 2: 1 TO 1: 2. IT ALSO REFERS TO THE POLYMORPHES OF FORMS A, B, C AND AMORPHO OF THE SALT ORTHOPHOSPHATE OF THE COMPOUND AND PROCEDURES FOR OBTAINING SAID POLYMORPHES; AND A PHARMACEUTICAL COMPOSICON FOR THE TREATMENT OF PAIN, MIGRANE, DEPRESSION AND NEURODEGENERATIVE DISEASES |