| abstract |
REFERS TO A COMPOUND OF FORMULA (I) WHERE R1 IS 2,6-DICHLOROPHENYL, 2,6-DIFLUOROPHENYL, 2,3,6-TRISUSTITED PHENYL WITH FLUORINE, CHLORINE, METHYL OR METHYL, AMONG OTHERS; R2a AND R2b ARE EACH H OR METHYL; R3 IS 2-PYRAZINYL, 5-PYRIMIDINYL, CYCLOHEXYL, TETRAHYDROTHIOPYRAN-4-ILO, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: (1-METHYL-PIPERIDIN-4-IL) -AMIDE OF THE ACID OF THE ACID 4- (2,3,6-TRICHLORO-BENZOIL-AMINO) -1H-PIRAZOL-3-CARBOXILICO; (1-METAN-SULFONYL-PIPERIDIN-4-IL) -AMIDE OF THE ACID 4- (2-CHLORO-6-FLUORO-BENZOIL-AMINO) -1H-PIRAZOL-3-CARBOXILICO; [1- (2-DIMETHYL-AMINO-ETANSULFONIL) -PIPERIDIN-4-IL] 4- (2,6-DICHLORO-BENZOYL-AMINO) -1H-PIRAZOL-3-CARBOXYL ACID AMIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE INHIBITED OF THE CYCLINE-DEPENDENT KINASE (CDK1 AND CDK2) AND OF THE GLYCOGEN SYNTHASE-3 KINASE (GSK3) AND ARE USEFUL IN THE TREATMENT OF DISEASES THAT INVOLVE ABNORMAL CELL GROWTH |