| abstract |
REFERRING TO A COMPOUND OF FORMULA (I), WHERE X IS N AND Y IS CH, OR X IS CH Y Y IS N; Z IS O, S, SO, or SO2; R1 IS CO2H, CH2CO2H, TETRAZOLE, AMONG OTHERS; R2a AND R2b ARE H, HALO, CN, NO2, AMONG OTHERS; R3a AND R3b ARE H, HALO, C1-C8 ALKYL, AMONG OTHERS; Rx IS C1-C8 ALKYL, C3-C8 ALKYL, C3-C8 ALKYL, AMONG OTHERS; R8 IS H, FLUORINE, OR C1-C8 ALKYL; R9 IS H, HYDROXY, FLUOR, AMONG OTHERS; R8 AND R9 TOGETHER WITH THE CARBON ATOM TO WHICH THEY ARE BINDED, FORM A CYCLOALKYL RING CONTAINING UP TO ONE HETEROATOM SELECTED FROM O, S, NH, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 6 - ({5-CHLORO-2 - [(PHENYLMETHYL) OXY] PHENYL} METHYL) -2-PYRIDINECARBOXYL ACID, 6 - ({5-CHLORO-2 - [(2-METHYL-2-PROPEN -1-IL) OXY] PHENYL} METHYL) -2-PYRIDINECARBOXYL, 6 - [(5-CHLORO-2 - {[(4-CHLORO-2-FLUOROPHENYL) METHYL] OXY} PHENYL) METHYL] -2-PYRIDINECARBOXYLATE SODIUM, AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE ANTAGONISTS OF THE EP1 RECEPTOR AND ARE USEFUL IN THE TREATMENT OF DISEASES MEDIATED BY PGE2 PROSTAGLANDINS SUCH AS ACUTE AND CHRONIC PAIN, ARTHROMYALGIA, NEUROPATHIC PAIN, VISCERAL PAIN, AMONG OTHERS |