| abstract |
REFERRING TO INDOLINONE COMPOUNDS OF FORMULA I, WHERE X IS O O S; R1 IS H O A PROFARMACO GROUP; R2 IS CARBOXY, C1-C6-CARBONYL ALCOXY, AMONG OTHERS; R3 IS H, C1-C6 ALKYL, C3-C7 CYCLOALKYL, AMONG OTHERS; R4 IS C3-C7 CYCLOALKYL; R6 IS H, F, CYANE, AMINO, AMONG OTHERS; R5 IS H, C1-C3 ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 3-Z- [1- (4- (PIPERIDIN-1-IL-METHYL) -ANILINE) -1-PHENYL-METHYLENE] -6-ETOXICARBONYL-2-INDOLINONE, 3-Z - [(1- (4- (PIPERIDIN-1-IL-METHYL) -ANILINE) -1-PHENYL-METHYLENE] -6-CARBAMOYL-2-INDOLINONE, AMONG OTHERS. IT IS ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE USEFUL FOR THE TREATMENT OR PREVENTION OF SPECIFIC FIBROTIC DISEASES |