| abstract |
REFERRING TO AN ANALOGUE COMPOUND OF RAPAMYCIN OF FORMULA I, WHERE R1 AND R2 ARE OR3 OR N (R3 ') (R3 "), AMONG OTHERS; R3, R3 'AND R3 "ARE H, C1-C6 ALKYL, C3-C8 CYCLOALKYL, AMONG OTHERS; R4 AND R4 'ARE H, OH, O (ACILO), O (ARYL), AMONG OTHERS; R5, R6 AND R7 ARE H, OH OR OCH3; R8 AND R9 ARE CONNECTED VIA (i) A SINGLE LINK AND ARE CH2 OR (ii) A DOUBLE LINK AND ARE CH; R15 IS C = O, CHOH AND CH2; n IS 1 O 2. THE PREFERRED COMPOUNDS ARE: 9,27-DIHYDROXY-3- {2- [4-HYDROXY-3-METOXICICLOHEXYL] -1-METHYLETHYL} -10,21-DIMETOXY-6,8,12,14, 20,26-HEXAMETHYL-37-PHENYL-4,9,10,12,13,14,15,18,21,22,23,24,25,26,27,32,33,34,34a-NONADECAHYDRO- 3H-23,27-EPOXY-18,15- (EPOXYIMINO) PYRID [2,1-c] [1,4] OXAZACICLOHENTRIACONTIN-1,5,11,28,29 (6H, 31H) -PENTONE, 9.27 -DIHYDROXY-3- {2- [4-HYDROXY-3-METOXICICLOHEXYL] -1-METHYLETHYL} -10,21-DIMETOXY-6,8,12,14,20,26-HEXAMETHYL-37-PHENYL-4,9 , 10,12,13,14,15,16,17,18,21,22,23,24,25,26,27,32,33,34,34a-HENICOSAHIDRO-3H-23,27-EPOXI-18 , 15- (EPOXYIMINO) PYRIDO [2,1-c] [1,4] OXAZACICLOHENTRIACONTIN-1,5,11,28,29 (6H, 31H) -PENTONE, AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL FOR THE TREATMENT OF NEUROLOGICAL DISORDERS OR COMPLICATIONS DUE TO CEREBROVASCULAR ACCIDENTS OR HEADACHE INJURIES, BENIGN OR MALIGNANT NEOPLASTIC DISEASES, CARCINOMAS AND PROVIDING INFLUENCIES, INFLUENCIES |