| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R1 IS C1-C8 ALKYL, C2-C8 ALKENYL, C2-C8 ALKINYL, C3-C8 CYCLOALKYL, AMONG OTHERS; R2 IS C1-C3 ALKYL, BENZYL, DISUSTITUTED BENZYL, TRISUSTITUTED BENZYL, AMONG OTHERS; R3 IS H, C1-C6 ALKYL SUBSTITUTED OR NOT WITH C3-C8 CYCLOALKYL, 1-3 FLUOR; R4 IS H, C1-C6 ALKYL OR R3 AND R4 TOGETHER TO THE CARBON TO WHICH THEY ARE UNITED FORM A C3-C6 CYCLOALKYL RING; R5 IS H, C1-C10 ALKYL SUBSTITUTED OR NOT, AMONG OTHERS; R6 IS H, PHENYL; G ES O, S (O) 0-2. THE PREFERRED COMPOUNDS ARE: THIRD-BUTYL ACID ESTER (2R, 5R) -5 - [(1S, 2S) -2-ACETYLAMINO-1-BENZYLOXY-3- (3,5-DIFLUOROPHENYL) PROPYL] -2-ISOBUTOXIMORPHOLINA-4 -CARBOXYL; (2S, 5R) -5 - [(1S, 2S) -2-ACETYLAMINE-3- (3,5-DUFLUOROPHENYL) -1-HYDROXYPROPYL] -2- (3-METHYLBUTOXY) MORPHOLIN-4 TERC-BUTYL ESTER -CARBOXYL; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE INHIBITORS OF THE BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVAGE ENZYME (BACE) USEFUL IN THE TREATMENT OR PREVENTION OF ALZHEIMER |