abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE Ar1 IS PHENYL, HETEROCYCLYL SUBSTITUTED OR NOT BY HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXI, AMONG OTHERS; T IS (CH2) n, CH3OH, N- (C1-C4 ALKYL), AMONG OTHERS; n IS 0-2; Ar2 IS PHENYL SUBSTITUTE OR NOT BY HALOGEN, C1-C4 ALKYL, AMONG OTHERS OR PYRINIDYL SUBSTITUTED BY C1-C4 ALKYL, C1-C4 ALCOXY; Ar3 IS PHENYL AND NAPHTHYLL, SUBSTITUTED OR NOT BY HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXY, NITRO, AMONG OTHERS; R1 IS CO-CF3 OR A GROUP OF FORMULA A WHERE n IS 0-3; R7 IS H, C1-C4 ALKYL, F, C1-C4 ALCOXY, AMONG OTHERS; R8 IS H, F, C1-C4 ALKYL, AMONG OTHERS; R9 IS H, HYDROXYL, C3-C6 CYCLOALKYL, C1-C4 ALCOXY, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N- {4-CHLORO-2 - [(2-CHLOROPHENYL) (HYDROXY) METHYL] PHENYL} -N - [(3,4-DIMETHOXYPHENYL) SULFONYL] ETHYL GLYCINATE; N- {4-CHLORO-2 - [(2-CHLOROPHENYL) (HYDROXY) METHYL] PHENYL} -N - [(2-ETHYL-2H-TETRAZOL-5-IL) METHYL] -3,4-DIMETOXIBENZENSULFONAMIDE; ETHYL N- {4-CHLORO-2 - [(3-CHLOROPHENIL) (HYDROXY) METHYL] PHENYL} -N - [(3,4-DIMETOXYPHENYL) SULFONYL] GLYCINATE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE ANTAGONISTS OF OREXIN 2 RECEPTORS, USEFUL IN THE TREATMENT OF OBESITY, DISORDERS OF THE APPETITE OR TASTE, HUMOR AND BEHAVIOR DISORDERS, LEARNING AND MEMORY DISORDERS |