abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE Q1 AND Q2 ARE EACH H, A RESIDUE OF SUGAR, S (O) t-OH; t IS 0-2; R1 IS H, HYDROXYL, HALOGEN, AMONG OTHERS; R2 AND R2a ARE EACH H, HYDROXYL, HALOGEN, C1-C6 ALKYL, C1-C4 ALCOXY, C2-C7 ALKINYL, AMONG OTHERS; R3 AND R3a ARE EACH H, C1-C3 ALKYL, C2-C7 ALKYL, HALOGEN, C1-C4 ALCOXY, AMONG OTHERS; X IS O, S, NH, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 2- (3'-FLUORO-4'-GLYCURONIDE PHENYL) -7-VINYL-1,3-BENZOXAZOLE-5-GLUCURONIDE; 2- (3'-FLUORO-4'-PHENYL SULPHATE) -7-VINYL-1,3-BENZOXAZOLE-5-SULPHATE; 2- (2'-FLUORO-4'-HYDROXYPHENYL) -7-VINYL-1,3-BENZOXAZOLE-5-GLUCURONIDE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE USEFUL MODULATORS OF THE ESTROGEN RECEPTOR IN METABOLIC DISORDERS SUCH AS LIPID METABOLISM, APPETITE, BLEEDING DISORDERS SUCH AS HEREDITARY HEMORRHAGIC TELANGIECTASIA, DYSFUNCTIONAL UTERUS BLEEDING, BETWEEN |