| abstract |
REFERS TO THIAZOL COMPOUNDS OF FORMULA (I), WHERE p IS FROM 0 TO 3, L2 IS -XOX-, -XS (O) 0-2X AND XS (O) 2-2XO-, WHERE X IS INDEPENDENTLY A LINK AND ALKYLENE (C1-C4); R13 IS ALKYL (C1-C6), ALCOXYL (C1-C6) AND HALOGEN; R14 IS -XOXC (O) OR17 AND -XC (O) OR17, WHERE X EA ALKYLENE (C1-C4), R17 IS H OR (C1-C6) ALKYL; R15 AND R16 ARE INDEPENDENTLY -R18 AND -YR18, WHERE AND IS ALKYLENE (C1-C6), ALKYLENE (C2-C6), -C (O) NH, AMONG OTHERS; R18 IS ARYL (C6-C10), CYCLOALKYL (C3-C12), AND HETEROARYL (C5-C43) SUCH AS PHENYL, BIPHENYL, CYCLOHEXYL, NAPHTHYL, BENZO [1,3] DIOXOL-5-ILO, FURANIL, AMONG OTHERS OPTIONALLY REPLACED. PREFERRED: {4- [4- (4-ISOPROPOXY-PHENYL) -5- (4-TRIFLUORO-METHOXY-PHENYL) -THAZOL-2-ILMETOXY] -2-METHYL-PHENOXY} -ACETIC ACID, {4- [4- (6-METHOXY-PYRIDIN-3-IL) -5- (4-TRIFLUORO-METOXY-PHENYL) -THAZOL-2-ILMETOXI] -2-METHYL-PHENOXY} -ACETICO, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT MAY ALSO CONTAIN ANOTHER ACTIVE AGENT SUCH AS ANTIDIABETICS, HYPOLIPIDEMICS, APPETITE REGULATORS, AMONG OTHERS. THESE COMPOUNDS ARE MODULATORS OF THE ACTIVITY OF THE RECEPTOR ACTIVATED BY PEROXISOMAS PROLIFERATOR, SPECIFICALLY OF PPAR *, SO THEY ARE USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, HYPERCHOLESTEREMIA, HYPERLIPIDEMIA, HEART FAILURE AND RELIEF ENDING, OBEDADENSATION, HYPERTENSION |