| abstract |
IT REFERS TO A COMPOUND OF FORMULA I, WHERE A IS A C1-C4 ALKYLENE GROUP SUBSTITUTED OR NOT WITH 1 TO 4 SELECTED SUBSTITUENTS OF HALOGEN, C1-C4 ALKYL, AMONG OTHERS; R1 IS ISOPROPYL, CYCLOPENTILO; R2 IS H, HALOGEN, HYDROXY; R3 IS CARBOXI, TETRAZOLYL, AMONG OTHERS; m IS 1-2. PREFERRED COMPOUNDS ARE: ACID 4 - {[4 - ({[(3-ISOPROPYL-2-OXO-2,3-DIHYDRO-1H-BENZYMIDAZOL-1-IL) CARBONYL] AMINO} METHYL) PIPERIDIN-1-IL] METHYL } TETRAHYDRO-2H-PYRAN-4-CARBOXYL; 1 - {[4 - ({[(3-ISOPROPYL-2-OXO-2,3-DIHYDRO-1H-BENZYMIDAZOL-1-IL) CARBONYL] AMINO} METHYL) PIPERIDIN-1-IL] METHYL} CYCLOHEXANOCARBOXYL ACID; 1 - {[4 - ({[(3-ISOPROPYL-2-OXO-2,3-DIHYDRO-1H-BENZYMIDAZOL-1-IL) CARBONYL] AMINO} METHYL) PIPERIDIN-1-IL] METHYL} CYCLOPENTHANOCARBOXYL ACID, BETWEEN OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. SUCH COMPOUNDS ARE AGONISTS OF THE 5-TH4 RECEPTOR, USEFUL IN THE TREATMENT OF GASTROINTESTINAL DISEASES, CNS, CARDIOVASCULAR DISORDERS, AMONG OTHERS |