| abstract |
REFERRING TO COMPOUNDS DERIVED FROM INDAZOLE AND INDOLONE FROM FORMULA I WHERE A IS N O C = O; X IS H, METHYL, ETHYL, AMONG OTHERS; --- REPRESENTS A SIMPLE LINK WHEN A IS N AND IS ABSENT WHEN A IS C = O; R1 IS SELECTED FROM (II), (III) AND (IV) WHERE Z IS O OR CH2; R2 IS H OR C1-C6 ALKYL, AMONG OTHERS; R3 IS H OR C1-C6 ALKYL, AMONG OTHERS; R4 IS H O C1-C6 ALKYL; R5 IS H, METHYL, ETHYL, METHOXY, OR ETOXY; R6 IS C1-C6 ALKYL; R7 IS H OR C1-C6 ALKYL, AMONG OTHERS; R8 IS H, C1-C6 ALKYL, PHENYL O (CH2) PHENYL; IN WHICH HETEROARILO IS AN AROMATIC RING OF 5 TO 7 MEMBERS THAT CONTAINS FROM 1 TO 4 HETEROATOMS SELECTED FROM 0, S AND N; UNDER THE CONDITIONS THAT Z IS OR WHEN A IS C = O AND WHEN A IS C = O, X IS H AND R1 IS (IV), THEN R5 CANNOT BE H. IT ALSO REFERS TO COMPOSITIONS THAT INCLUDE THESE COMPOUNDS WHOSE PREFERRED ARE 4 - [(2R, 5S) -5-METHYL-4-PROPYLMORFOLIN-2-IL] -1H-INDAZOLE, 4- [1- (2-ETHYL) AZETHYL-3-IL] -1H-INDAZOLE, 4- [1 - (3-PHENYLPROPYL) AZETIDIN-3-IL] -1H-INDAZOLE, AMONG OTHERS. SUCH COMPOUNDS ARE SELECTIVE AGONISTS OF DOPAMINE D3 RECEPTORS AND ARE USEFUL FOR THE TREATMENT OF SEXUAL DYSFUNCTION |