abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE X IS S, SO2; R1 IS C1-C6 ALKYL, C3-C6 ALKENYL OR C3-C6 ALKYL, OPTIONALLY SUBSTITUTED; R2 IS H, C1-C4 ALKYL, CO- (C1-C4 ALKYL); R3 IS PHENYL REPLACED WITH C1-C4 ALKYL, C1-C4 FLUOROALKYL, HALOGEN, AMONG OTHERS; R4 IS AROMATIC PHENYL OR HETEROCICLO WITH 6 MEMBERS, REPLACED IN ORTHO POSITION WITH 1-HYDROXY (C1-C4 ALKYL), C1-C4 ALCOXY, CO2 (C1-C4 ALKYL), CONH2, AMONG OTHERS; R8, R9, R10 ARE EACH H, C1-C2 ALKYL, FLUORINE, CHLORINE. PREFERRED COMPOUNDS ARE: [1- (3,5-DIFLIDE-BENZYL) -3- (2-NITRO-PHENYLSULFANIL) -1H-INDOL-6-IL] -MEthylamine; [1-FURAN-2-ILMETHYL-3- (2-NITRO-PHENYLSULFANIL) -1H-INDOL-6-IL] -MEthyl-AMINE; [1- (3,5-DIFLIDE-BENZYL) -3- (2-NITRO-PHENYLSULFANIL) -1H-INDOL-6-ILAMINO] -ACETONITRILE; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS HAVE AFFINITY FOR THE ANDROGEN RECEPTOR USEFUL IN THE TREATMENT OF MALE AND FEMALE HORMONE REPLACEMENT THERAPY AND THERAPY OF ANDROGEN RECEPTOR-RELATED CONDITIONS, DISORDERS AND DISEASES |