| abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE A IS O, S; X IS O, S; Q IS A HETEROCYCLE CONSISTENT OF 2 OR 3 CONDENSED RINGS, IN EACH CASE OF 4-8 MEMBERS, SATURATED, PARTIALLY OR TOTALLY INSATURATED, INDEPENDENTLY ONE OF THE OTHER, WHERE THE HETEROCYCLE PRESENTS 1-5 HETEROATOMS, SELECTED AMONG O, N, S; R1 IS HETEROCICLO AZA, DIAZA, OXAZA, S, S-DIOXIDO-TIADIAZA, AMONG OTHERS; R2 IS H, PHENYLMETHYL, SUBSTITUTED C2-C7 ALKYL, AMONG OTHERS; R3 IS H, C1-C3 ALKYL SUBSTITUTED, AMONG OTHERS. PREFERRED COMPOUNDS ARE: ESTER (R) -1- (7-METHYL-1H-INDAZOL-5-ILMETYL) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2 -OXO-ETHYL OF 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) PIPERIDIN-1-CARBOXYL ACID; ESTER (R) -1- (4-AMINO-3-METHYL-5-NITRO-BENZYL) -2- [4- (4-METHYL-PIPERAZIN-1-IL) -PIPERIDIN-1-IL] -2-OXO - 4- (2-OXO-1,2,4,5-TETRAHYDRO-1,3-BENZODIAZEPIN-3-IL) PIPERIDIN-1-CARBOXYL ACID ETHYL; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE USEFUL ANTAGONISTS OF CGRP IN THE ACUTE OR PROPHYLACTIC TREATMENT OF HEADACHES, CARDIOVASCULAR DISEASES, ARTHRITIS, AMONG OTHERS |