abstract |
REFERS TO A COMPOUND OF FORMULA I, WHERE R2 AND R5 ARE EACH H, HALOGEN, C1-C6 ALKYL, ARYL, AMONG OTHERS; R4 IS HALOGEN, H, C3-C8 CYCLOALKYL, ARALKYL, ARYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: ACID (3R, 5R) -7- [2- (4-FLUORO-PHENYL) -5-ISOPROPYL-4- (2-METHOXY-ETHYLCARBAMYL) -IMIDAZOL-1-IL] -3,5-DIHYDROXY -HEPTANOIC; (3R, 5R) -7- [2- (4-FLUORO-PHENYL) -5-ISOPROPYL-4 - ((S) -1-METHYL-3-PHENYL-PROPYLCARBAMYL) -IMIDAZOL-1-IL] -3 ACID , 5-DIHYDROXY-HEPTANOIC; (3R, 5R) -7- [4-BENZYLCARBAMYL-5-CYCLOPROPYL-2- (4-FLURO-PHENYL) -IMIDAZOL-1-IL] -3,5-DIHYDROXY-HEPTANOIC ACID; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE USEFUL INHIBITORS OF CHOLESTEROL BIOSYNTHESIS IN THE TREATMENT OF HYPERLIPIDEMIA, HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS |