| abstract |
REFERS TO COMPOUNDS THAT CONTAIN A SULFONE GROUP OF FORMULA (I), WHERE R1 IS ARYL OR HETEROARYL, OPTIONALLY SUBSTITUTED BY ONE OR MORE R5; R2 ES - (C0-C12) ALKYLEN-C (O) -Y, - (C0-C6) ALKYLEN- (C3-C6) CYCLOALKYLENE- (C0-C6) ALKYLEN-C (O) -Y, - (C0- C12) RENT-S (O2) -Y, - (C0-C6) RENT- (C3-C6) CYCLOALKYLEN- (C0-C6) RENT-S (O2) -Y, AMONG OTHERS, WHERE THE RENTAL OR CYCLE RENTAL ARE OPTIONALLY REPLACED BY HYDROXY; AND IS a), b), c), d), AMONG OTHERS; EACH R3 OF (R3) 2 IS SELECTED FROM H, OH, ALKYL OR ACILO (C1-C6); PART (R3) 2 NEXT TO THE C ANNULAR DEFINES A CARBONYL, ONLY IF WHEN m IS GREATER THAN 1, AT THE MOST ONE CARBONYL IS PRESENT; EACH R3A AND R3B IS INDEPENDENTLY H OR ALKYL (C1-C6); R5 IS HALO, OH, CF3 AND -0- (C1-C6). IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE INHIBITORS OF THE GAMMA SECRETASE AND ARE USEFUL IN THE TREATMENT OF ALZHEIMER'S EVIL |