abstract |
REFERS TO COMPOUNDS DERIVED FROM 7-PHENYLAMINE-4-QUINOLONE-3-CARBOXYL ACID, FROM FORMULA (I), WHERE R1 IS OH, O-ALKYL (C1-C6) OR O-ALKYL (C1-C6) -OCO -ALKYL (C1-C6); R2 IS H, (C1-C6) ALKYL; R3 IS H, ALKYL (C1-C8), CYCLOALKYL (C3-C7), PYRIDYL OR PHENYL, AMONG OTHERS; R5 IS H, F, Cl, (C1-C6) ALKYL; R6 IS H, F, Cl, AMONG OTHERS; R7 IS H O (C1-C6) ALKYL; R8 IS PHENYL, WHICH CAN BE SUBSTITUTED UP TO 5 TIMES WITH F, Cl, NO2, O-ALKYL (C1-C8), NH-ALKYL (C1-C6), AMONG OTHERS; X IS N O C-R4 (R4 IS H, HALOGEN, NO2, AMONG OTHERS). PREFERRED COMPOUNDS ARE: 1-ETHYL-6- (4-ETHYLPHENYLAMINE) -7-METHYL-4-OXO-1,4-DIHYDRO- [1,8] NAPHTHYRIDINE-3-CARBOXYLATE, 1-ETHYL-6- (4- METHOXY-2-METHYLPHENYLAMINE) -8-METHYL-4-OXO-1,4-DIHYDROQUINOLONE-3-CARBOXYLATE, METHYL-1-ETHYL-6- (4-METHOXY-2-METHYLPHENYLAMINE) -8-METHYL-4- OXO-1,4-DIHYDROQUINOLONE-3-CARBOXYL. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION, WHICH MAY ALSO CONTAIN ANOTHER ACTIVE INGREDIENT SUCH AS ANTIDIABETICS, HYPOGLUCEMIANS, HMGCoA REDUCTASE INHIBITORS, AMONG OTHERS. THESE COMPOUNDS ARE INHIBITORS OF GLUCOGENE PHOSPHORYLASE (GPa), SO THEY ARE USEFUL IN THE PREVENTION AND TREATMENT OF TYPE 2 DIABETES |