| abstract |
REFERS TO COMPOUNDS OF FORMULA (IA), WHERE R1 IS ARYL OR HETEROARYL, SUCH AS PHENYL, THENYL, NAPHTHYL, DIHYDROBENZOFURANIL, CHROMANIL, AMONG OTHERS, OPTIONALLY SUBSTITUTED BY Cyl3, CLCYL, ALKYL (C1-A, ALKYL) (C1-A, ALKYL) ALKENYLOXY (C2-C3), HALOGEN, CYANE, ARYL, HETEROARYL, AMONG OTHERS; R2 AND R3 ARE INDEPENDENTLY, H, ALKYL (C1-C5) OR TOGETHER WITH THE C TO WHICH THEY ARE UNITED, THEY FORM A CYCLOALKYL SPIRO RING (C3-C8); R4 IS ALKYL (C1-C5), AMONG OTHERS; R5 IS A HETEROARYL LIKE PYRIDYL, INDOLYL, AZAINDOLYL, DIAZAINDOLYL, AMONG OTHERS, OPTIONALLY SUBSTITUTED BY METHYL, PHENYL, METOXY, ETOXY, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 1,1,1-TRIFLUORO-4- (5-FLUORO-2-METOXYPHENYL) -4-METHYL-2- (3-METHYL-1H-PYRROLO [3,2-c] PYRIDIN-2-ILMETHYL ) PENTAN-2-OL, 4- (5-CHLORO-2,3-DIHYDROBENZOFURAN-7-IL) -1,1,1-TRIFLUORO-4-METHYL-2- (5-TRIFLUORORMETHYL-1H-PIRROLO [2, 3-c] PYRIDIN-2-ILMETHYL) PENTAN-2-OL, 1,1,1-TRIFLUORO-5-METOXY-4-METHYL-4-PHENYL-2-QUINOLIN-4-ILMETILPENTAN-2-OL, AMONG OTHERS . IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCESS. THESE COMPOUNDS ARE MODULATORS OF THE GLUCOCORTICOID RECEPTOR SO THEY ARE USEFUL IN THE TREATMENT OF ALLERGIC OR PROLIFERATIVE INFLAMMATORY PROCESSES |