| abstract |
REFERRED TO A METHOD OF MODULATION (INHIBITION) OF A METALOPROTEIN WHERE A METALOPROTEINASE IS BINDED, SUCH AS GELATINASE A, MACROPHAGUS METALOELASTASE, COLLAGENASE-3, AMONG OTHERS; WITH A QUANTITY OF BIARYL SULFONAMIDE ATTACHED TO A HETEROARYL GROUP SUCH AS FURAN, 1,2,4-OXADIAZOLE, IMIDAZOLE, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N - ({4 '[1-BENZOFURAN-2-ILCARBONYL) -AMINO] -1,1'-BIPHENYL-4-IL} -SULFONYL) -GLYCIN, L-2- {4' ACID - [ (BENZOFURAN-2-CARBONYL) -AMINO] -BIPHENYL-4-SULFONYLAMINE} -3-METHYL-BUTYRICO, AMONG OTHERS. SAID COMPOUNDS ARE USEFUL IN THE TREATMENT OF OSTEOARTHRITIS, ASTHMA, OBSTRUCTIVE PULMONARY DISEASE, AMONG OTHERS |