http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20050555-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-02 |
filingDate | 2004-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d726441ded5c62dc0681a3bf351e4fc |
publicationDate | 2005-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | PE-20050555-A1 |
titleOfInvention | N-ARYLSULFONYLPIPERIDINE BRIDGED COMPOUNDS AS GAMMA-SECRETASE INHIBITORS |
abstract | REFERS TO COMPOUNDS CONTAINING A BRIDGE DERIVED FROM N-ARYLSULFONYLPIPERIDINES OF FORMULA (I), WHERE Ar IS ARYL OR HETEROARYL; X IS O, NH O NR6; m IS FROM 0 TO 3, PROVIDED THAT WHEN IT IS 0, THERE IS NO DOUBLE LINK, AND IF m> 0, THERE MAY BE DOUBLE OR TRIPLE LINK; n IS 0 TO 3; R1 IS 1 TO 3 HALOGEN SUBSTITUTES, H, CYCLOALKYL, HALOGEN, -CF3, -NR6R7, CN, AMONG OTHERS; R2 IS H, ALKYL, CYCLOALKYL, ALKYLEN-CYCLOALKYL, AMONG OTHERS; R3 IS H, HALOGEN, CYCLOALKYL, -OH, -OCF3, AMONG OTHERS; R4 IS H, ALKYL, CYCLOALKYL, ARYL OR HETEROARYL OR R3 AND R4 TOGETHER FORM A RING OF 3 TO 6 MEMBERS; R5 IS -NR6R7, -N (R6) -ALKYLENE-NR6R7, ALKYL, HETEROARYL, BETWEEN OTHERS OR A RADICAL PYRROLIDINYL, PIPERIDINYL, MORPHOLINYL, PIPERAZINYL, BETWEEN OTHERS, OPTIONALLY SUBSTITUTE R9, WITH R9. PREFERRED COMPOUNDS ARE: 2- (N-2-HYDROXYETHYL) PIPERAZIN-1-CARBOXYL] -9- [4-CHLORO-BENZENSULFONYL] -AZABICYCLO- [3,3,1] -NONATE, AMONG OTHERS. THESE COMPOUNDS ARE INHIBITORS OF GAMMA SECRETASE, THEREFORE INHIBIT THE DEPOSITION OF BETA-AMYLOID PROTEIN AND ARE USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER |
priorityDate | 2003-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Predicate | Subject |
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isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419694116 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID8082 |
Total number of triples: 21.