abstract |
REFERS TO N-HETEROCICLO DERIVATIVES SUBSTITUTED FOR FORMULA I, WHERE IS PHENYL, NAPHTHYL, THIOPHENYL, PYRIDINYL, FURANIL, AMONG OTHERS; U IS N or O; W IS H or R8; R1 AND R2 ARE H, OH, ALKYL, ALCOXY, HALO, TRIFLUOROMETHYL, AMONG OTHERS; R3 AND R4 ARE H, C1-C6 ALKYL, BENZYL, NAPHTHYL METHYL, AMONG OTHERS; R5 IS H, C1-C6 ALKYL, HALO or TRIFLUOROMETHYL; R6 AND R7 ARE C1-C6 ALKYL, C3-C6 CYCLOALKYL; t IS 1, 2 or 3; x IS 0, 1 or 2; and ES 0, 1 or 2; z IS 0, 1 or 2. PREFERRED COMPOUNDS ARE: 1- [2- (1,4'-BIPIPERIDIN-1'-IL) -1- (3-CHLOROPHENYL) ETHYL] CYCLOHEXANOL DICHLORHYDRATE; 1- [1- (3-CHLOROPHENYL) -2- (4-PYRROLIDIN-1-IL-PIPERIDIN-1-IL) -ETHYL] CYCLOHEXANOL DICHLORHYDRATE; 1- [2- (1,4'-BIPIPERIDIN-1'-IL) -1- (3-BROMOPHENYL) ETHYL DICHLORHYDRATE] CYCLOHEXANOL; AMONG OTHERS. IT ALSO REFERS TO A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AND A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS IMPROVE MONOAMINE RECAPTATION |