http://rdf.ncbi.nlm.nih.gov/pubchem/patent/PE-20050345-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-26 |
| filingDate | 2004-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ece10327c1b4a8629ecdaf0d1999d735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_052374bc1d1d871f8bedb69db80ec5a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_186f72d25c36b6193032e5622ebaf6d4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52d75c54bab50253edbdad58a40289ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ccd6ae6942c162040ad5f28646c1538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4482efd050c6a541037909b7d53db5b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f74d7ed603a9c700fedd68e309b6132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0eb7a0eb2afc53eefe2acffeb240bc78 |
| publicationDate | 2005-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | PE-20050345-A1 |
| titleOfInvention | CYCLE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY |
| abstract | IT REFERS TO CYCLIC DERIVATIVES OF FORMULA I, WHERE RING B IS A C3-C8 CYCLOALKYL, HETEROCICLE OF 3-7 MEMBERS WITH HETEROATOMS SELECTED FROM O, S, S (= O), S (= O) 2, AMONG OTHERS; X IS O or S; Z IS NR8C (O), NR8C (S), NR8C (O) NH, NR8C (S) NH, AMONG OTHERS; WHERE NEITHER Z NOR R13 ARE CONNECTED TO AN ATOM OF C IN (b); A LINK (a) IS A SINGLE OR DOUBLE LINK; ALTERNATIVELY WHEN N IS 2, TWO ATOMS IN (b) JOIN THROUGH A DOUBLE LINK; R1 IS H, C1-C6 ALKYL, AMONG OTHERS; R2 IS C1-C6 ARYL or A 5-10 MEMBER HETEROARYL WITH 1-4 HETEROATOMS SELECTED FROM N, O, or S; R10 IS OH, SH, AMONG OTHERS; R11 IS H, C1-C4 ALKYL, AMONG OTHERS; R12 IS H; R13 IS H, C1-C4 ALKYL, OH, NH2, F, AMONG OTHERS; m IS 0 or 1; n IS 0, 1, 2 or 3; s IS 0 or 1. THE PREFERRED COMPOUNDS ARE: CIS- (3S) -1- (4- (TERT-BUTYLAMINE) CYCLOHEXYL) -3- (6- (TRIFLUOROMETHYL) QUINAZOLIN-4-ILAMINE) PYRROLIDIN-2-ONA; TRANS- (3S) -1- (4- (TERT-BUTYLAMINE) CYCLOHEXIL) -3- (6- (TRIFLUOROMETHYL) QUINAZOLIN-4-ILAMINE) PYRROLIDIN-2-ONA; CIS- (3S) -1- (4- (TERT-BUTYLAMINE) CYCLOHEXIL) -3- (6-TERBUTILPYRROLO [1,2-f] [1,2,4] TRIAZIN-4-ILAMINO) PYRROLIDIN-2-ONA ; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE MODULATORS OF CHEMOKINE ACTIVITY, ESPECIALLY OF THE MCP-1 RECEPTOR |
| priorityDate | 2003-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.