| abstract |
IT REFERS TO A PHARMACEUTICAL COMPOSITION FOR PARENTERAL ADMINISTRATION THAT INCLUDES A SOMATOSTATIN ANALOGUE THAT INCLUDES THE SEQUENCE OF AMINO ACIDS OF FORMULA I (D / L) Trp-Lys-X1-X2 WHERE X1 IS A RADICAL OF FORMULA A, WHERE X1 IS A RADICAL OF FORMULA A PHENYL; R2 IS -Z1-CH2-R1, -CH2-CO-O-CH2-R1 WHERE Z1 IS O, S; X2 IS AN O-AMINO ACID THAT HAS AN AROMATIC RESIDUE IN THE SIDE CHAIN OF CO, AN AMOUNT OF AMINO ACID SELECTED FROM Dab, Dpr, Dpm, His, (Bzl) HyPro, thienyl-Ala, cyclohexyl-ala, t-butyl-ala , AMONG OTHERS. IT ALSO REFERS TO A COMPOUND OF FORMULA II AND A PARENTERAL COMPOSITION REGULATED IN ITS pH OF 4 TO 4.5 AND UNDERSTANDS AS ACTIVE INGREDIENT CYCLE [{4- (Nh2-C2H4-NH-CO-O-) Pro} -Phg- DTrp-Lys-Tyr (4-BzL) -phe] USEFUL FOR THE TREATMENT OF ACROMEGALIA OR CANCER |