| abstract |
REFERS TO RENTAL DERIVATIVES OF FORMULA I WHERE Q IS O, S, NR5; A IS A LIGATURE REPLACED BY R8; R1 AND R2 ARE H, HALO, C1-C6 ALKYL, C1-C6 ALCOXY, AMONG OTHERS; R3 IS H, C1-C6 ALKYL SUBSTITUTED BY OH, PHENYL WITH C1-C6 ALKYL, C1-C6 ALCOXY, AMONG OTHERS; R4 IS H, NITRO, C1-C6 ALKYL; R3 AND R4 TOGETHER TO THE ATOM OF C TO WHICH THEY ARE UNITED FORM A RING OF BENZENE WITH HALO, C1-C6 ALKYL, AMONG OTHERS; R5 IS H, C1-C6 ALKYL; R6 IS H; R7 IS H, C1-C6 ALKYL, C1-C6 ALCOXY, AMONG OTHERS; R8 IS C1-C6 ALKYL. PREFERRED COMPOUNDS ARE 4- [4 '- (1H-BENZYMIDAZOL-2-ILAMINE) -1,1'-BIPHENYL-4-IL] -2,2-DIMETHYL-4-OXOBUTANOIC ACID, 4- {4' - [ (5-METHOXY-1H-BENZYMIDAZOLE-2-IL) AMINO] -1,1'-BIPHENYL-4-IL} -2,2-DIMETHYL-4-OXOBUTANOIC, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. ALKYLARYL DERIVATIVES ARE INHIBITORS OF DIACILGLICEROL O-ACYLTRANSFERASE TYPE 1 (DGAT-1) AND ARE USEFUL IN THE TREATMENT OF OBESITY |