abstract |
REFERS TO SUBSTITUTED DIHYDROQUINAZOLINE FORMULA I WHERE Ar IS ARYL WITH 1 TO 3 SELECTED SUBSTITUENTS OF ALKYL, ALCOXY, FORMYL, CARBOXYL, AMONG OTHERS; R1 IS H, AMINO, ALKYL, ALCOXY, ALKYLAMINE, ALKYLTIO, AMONG OTHERS; R2 IS H, ALKYL, ALCOXY, CYANE, AMONG OTHERS; R3 IS AMINO, ALKYL, ALCOXY, ALKYLAMINE, ALKYLTIO, AMONG OTHERS; OR ONE OF THE R1, R2 AND R3 REMAINS IS H, ALKYL, ALCOXY, CYANE, BETWEEN OTHERS AND THE OTHER TWO TOGETHER WITH THE CARBON TO WHICH THEY ARE BINDED, FORMING A 1,3-DIOXOLANE, A CYCLOPENTAN RING OR A CYCLOHEXANE RING; R4 AND R5 ARE H or ALKYL; OR R4 AND R5 IN THE PIPERAZINE RING ARE UNITED WITH EXACTLY OPPOSITE CARBON ATOMS AND FORM A METHYLENE BRIDGE, SUBSTITUTED OR NOT WITH 1 TO 2 METHYL GROUPS; R6 IS ALKYL, ALCOXY, ALKYLTIO, FORMYL, CARBOXYL, AMINOCARBONYL, AMONG OTHERS; R7 IS H, ALKYL, ALCOXY, ALKYLTIO, FORMYL, CARBOXYL, ALKYLCARBONYL, AMONG OTHERS; R8 IS H, ALKYL, ALCOXY, ALKYLTIO, FORMIL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: {8-FLUORO-2- [4- (4-FLUOROPHENYL) -1-PIPERAZINYL] -3- [3- (TRIFLUORMETHYL) PHENYL] -3,4-DIHYDRO-4-QUINAZOLINYL} ACETIC ACID; {8-FLUORO-2- [4- (3-METHYLPHENYL) -1-PIPERAZINYL] -3- [3- (TRIFLUORMETHYL) PHENYL] -3,4-DIHYDRO-4-QUINAZOLINYL} ACETIC ACID; {8-FLUORO-2- [4- (3-METOXYPHENYL) -1-PIPERAZINYL] -3- [3- (TRIFLUORMETHYL) PHENYL] -3,4-DIHYDRO-4-QUINAZOLINYL} ACETIC ACID; AMONG OTHERS. IT ALSO REFERS TO A PREPARATION PROCEDURE. THESE COMPOUNDS ARE USEFUL AS ANTITIVIRAL AGENT AGAINST CYTOMEGALOVIRUS |