| abstract |
FORMULAS I, Ia AND Ib, INCLUDING THEIR SALTS, SOLVATES AND PROPHARMACES PHARMACEUTICALLY ACCEPTABLE, IN WHICH A IS C-X or N, REFERS TO MORPHOLINE DERIVATIVES; B IS C-Y or N; R1 IS H, C1-C6 ALKYL; R2 IS H, C1-C6 ALKYL; X IS H, OH, C (O) NH2, NH2; Y IS H, OH, NH2, Br, Cl, F; Z IS H, OH, F, CONH2, CN; WITH THE CONDITION THAT FOR A COMPOUND OF FORMULA I, Ia or Ib, WHEN A IS CX, B IS CY, R1 IS H or C1-C6 ALKYL, AND R2 IS H or C1-C6 ALKYL, AT LEAST ONE OF X , Y and Z MUST BE OH; AND FOR A COMPOUND OF THE FORMULA I, WHEN A IS C-X AND B IS C-Y, AND IS H, R1 IS H, AND R2 IS H, THEN X CANNOT BE OH. PREFERRED COMPOUNDS ARE: R - (-) - 3- (4-PROPYLMORPHOLIN-2-IL) PHENOL; S - (+) - 3- (4-PROPYLMORPHOLIN-2-IL) PHENOL; R-5- (4-PROPYLMORPHOLIN-2-IL) BENZENE-1,3-DIOL; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE DOPAMINE AGONISTS, IN PARTICULAR OF THE D3 RECEPTOR AND ARE USEFUL FOR THE TREATMENT AND / OR PREVENTION OF FEMALE AND MALE SEXUAL DYSFUNCTION, AS WELL AS TO TREAT NEUROPSYCHIATRIC AND NEURODEGENERATIVE DISORDERS |