| abstract |
IT REFERS TO A PHARMACEUTICAL COMPOSITION AND A COMPOUND OF FORMULA I WHERE R1 IS H, ACILO, ALCOXICARBONIL, AMONG OTHERS; R2 IS R1 AND ALKYL, SUBSTITUTED WITH HYDROXYCARBONYL OR ALCOXYCARBONYL; R3 AND R5 ARE EACH SINGLE CYCLE OR BICYCLE ARYL, OPTIONALLY REPLACED; R4 IS H, HYDROXY, ALCOXY, AMINO, SUBSTITUTED ALKYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: 5-ACETYL-2-ETHYL-4 - [(3-FLUOROPHENYL) AMINO] -6-PHENYLPYRIDAZIN-3 (2H) -ONE; 5-ACETYL-4 - [(3,5-DICHLOROPHENYL) AMINO] -2-ETHYL-6-PHENYLPYRIDAZIN-3 (2H) -ONE AND 5-ACETYL-2-ETHYL-4- (1-NAPHTHYLAMINE) -6- PHENYLPYRIDAZIN-3 (2H) -ONE. SUCH COMPOUNDS ARE INHIBITORS OF PHOSPHODIESTERASE 4 (PDE4) USEFUL IN THE TREATMENT, PREVENTION OR SUPPRESSION OF PATHOLOGICAL STATES SUCH AS ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, RHEUMATOID ARTHRITIS, AMONG OTHERS |