| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_616f93fd44c6397511f53b8856d69447 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-85 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-78 |
| filingDate |
2003-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_288bbe193ecc0d773805683dc0428a5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c68e66414841c4dbad469272c95f98
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f30ef0ce84cb270fca9941fe9173216e |
| publicationDate |
2004-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
PE-20040586-A1 |
| titleOfInvention |
PROCEDURE TO PREPARE NEVIRAPINE |
| abstract |
IT REFERS TO A PROCEDURE TO PREPARE NEVIRAPINE IN THE FOLLOWING STAGES: A) MAKE RECTION OF A 2-HALO-3-PYRIDINOCARBONITRILE WITH CYCLOPROPYLAMINE TO PROVIDE 2- (CYCLOPROPYLAMINE) -3-PYRIDINE CARBON (1); B) HYDROLIZE (1) TO PROVIDE 2- (CYCLOPROPYLAMINE) -3-PYRIDINE-CARBOXYL ACID (2); C) ISOLATE (2) FROM THE MEANS OF REACTION; D) TREATING (2) WITH A COLORING AGENT TO PROVIDE 2- (CYCLOPROPYLAMINE) -3-PYRIDINCARBONYL CHLORIDE (3); E) REACT (3) WITH A 2-HALO-4-METHYL-3-PYRIDINAMINE TO PRODUCE N- (2-HALO-4-METHYL-3-PYRIDINYL) -2- (CYCLOPROPYLAMINE) -3-PYRIDINECARBOXAMIDE (4) ; F) CYCLING (4) THROUGH TREATMENT WITH A STRONG BASE TO PROVIDE NEVIRAPINE. SUCH SYNTHESIS PROVIDES GREATER PERFORMANCE, GREATER SAFETY AND IS MORE ECONOMIC |
| priorityDate |
2002-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |