abstract |
IT REFERS TO THE USE OF N-SUBSTITUTED CYCLIC ALPHA IMINOCARBOXYL ACIDS OF FORMULA I TO PRODUCE A PHARMACEUTICAL PRODUCT FOR PROPHYLAXIS AND THERAPY OF AFFECTIONS IN WHICH ADVANCE IS INVOLVED AN INTENSIFIED ACTIVITY, SUCH AS TENSIFICED OSS, SPORTY 13 METALOPYLOPHYL OSTRYSTRIS TENSIFIED ACTIVITY, 13 METALOPYLOPHYL 13 OSPOLISTIC TENSIFIED TISTRYSM TILES 13 INJURIES OF THE JOINTS, PROLONGED IMMOBILIZATION OF THE JOINTS AFTER INJURIES OF THE MENISCUS OR KNEE OR TEAR OF THE LIGAMENTS, COLLAGENOSIS, PERIODONTAL AFFECTIONS, DISORDERS IN THE HEALING OF WOUNDS, CHRONIC DISORDERS OF THE INFLUENZA SYSTEM WITH METABOLISM, ARTHROPATHIES; WHERE TO IS CARBON, NITROGEN OPTIONALLY SUBSTITUTED WITH ALKYL; n IS 1-2; R1 IS ALKYL, ALKENYL, ALKINYL, ALKYL-PHENYL, ALKYL-CYCLOALKYL, CYCLOALKYL, CH2CF3; R2 IS H, RENT. IT ALSO REFERS TO COMPOUND I, AMONG OTHERS AND TO A PROCEDURE FOR THE PREPARATION. PREFERRED COMPOUNDS ARE 2- (4'-NITROBIPHENYL-4-SULFONIL) -1,2,3,4-TETRAHYDRO-ISOQUINOLIN-3- (R) -CARBOXYL ACID; METHYL 2- (4'-AMINOBIPHENYL-4-SULFONIL) -1,2,3,4-TETRAHYDRO-ISOQUINOLINYL-3- (R) -CARBOXYLATE; 2- (4'-ISOPROPOXICARBONYLAMINBIPHENYL-4-SULFONIL) -1,2,3,4-TETRAHYDROISOQUINOLIN-3- (R) -METHYL CARBOXYLATE |