| abstract |
REFERS TO HETEROARYL DERIVATIVES OF FORMULA I WHERE R IS R4-HETEROARYL, AMONG OTHERS; R1 IS H, C1-C6 ALKYL; R2 AND R3 ARE METHYL, METHOXY, HALO; R4 IS H, HALO, C1-C6 ALKYL, -CN, CF3, OCF3, AMONG OTHERS; R5 AND R6 ARE H, C1-C3 ALKYL; R7 IS C1-C3 ALKYL, C1-C3 AMINOALKYL. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. PREFERRED COMPOUNDS ARE 8- [BIS (2-CHLOROPHENYL) METHYL] -3- (2-PYRIMIDINYL) -8-AZABICYCLE [3.2.1] OCTAN-3-OL, 8- [BIS (2-CHLOROPHENYL) METHYL] -3 - (5-ETHYL-2-PYRIMIDINYL) -8-AZABICYCLE [3.2.1] OCTAN-3-OL, 8- [BIS (2-CHLOROPHENYL) METHYL] -3- (4- (1-PIPERAZINYL) -2- PYRIMIDINYL) -8-AZABICYCLO [3.2.1] OCTAN-3-OL, AMONG OTHERS. THE MENTIONED COMPOUNDS ARE SUPERIOR LIGANDS FOR THE NOCIPEPTIN RECEPTOR ORL-1 AND ARE USEFUL FOR THE TREATMENT OF COUGH, PAIN, ANXIETY, ASTHMA |