| abstract |
REFERS TO N- [BENZOYL] HETEROARYLSULFONAMIDE COMPOUNDS OF FORMULA I WHERE -X = Y IS -C (R4) = C (R3) -, -C (R5) = N-; R1 IS HALO, ALKYL, CF3, R2 IS HALO, NO2, ALKYL, CF3; R3 IS H, ALKYL, ALCOXY, ALKYLTIO, HALO; R4 IS H, HALO, ALCOXY, ALKYL, COO-ALKYL; R5 IS HALO, ALKYL, ALCOXI. PREFERRED COMPOUNDS ARE N- [2,4-DICHLOROBENZOYL] -5-BROMOTHIOPHEN-2-SULFONAMIDE; N- [4-CHLORO-2-METHYLBENZOYL] -5-CHLOROTHIOPHEN-2-SULFONAMIDE; THE COMPOUNDS MAY BE USEFUL FOR THE TREATMENT OF SUSCEPTIBLE NEOPLASMS, TUMORS, CARCINOMAS, GLIOBLASTOMA MULTIFORME, ASTROCITOMA, PINEAL TUMORS |