abstract |
REFERS TO AMIDE DERIVATIVES OF ANTRANILIC ACID OF FORMULA I WHERE Ar IS BENZAMIDE REPLACED WITH Ra; Ra IS H, ALKYL; R1 IS H, PERFLUOROALKYL; R2 IS H, HALOGEN, ALKYL, ALKENYL, ALKINYL; O Ar IS PYRIDINYL WHERE R1 IS PERFLUOROALKYL; R2 IS Br, I, ALKYL, ALKENYL, ALKINYL; R1 IS H, R2 IS F, Cl, Br, I, ETHYL, ALKYL, ALKENYL, ALKINYL; PREFERRED COMPOUNDS ARE 2- [4-PYRIDINYLMETHYL] AMINO-N- [4-BROMO-3- (TRIFLUORomethyl) PHENYL] BENZAMIDE; 2 - [[3 - [(METHYLAMINE) CARBONYL] -PHENYL] METHYL] -AMINO-N- [3- (TRIFLUOROMETHYL) PHENYL] BENZAMIDE; 2- [4-PYRIDINYLMETHYL] AMINO-N- [4- (1-PROPINYL) -3- (TRIFLUORomethyl) PHENYL] BENZAMIDE; AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE COMPOUNDS ARE INHIBITORS OF VEGF RECEPTOR TYROSINCINASE ACTIVITY AND MAY BE USEFUL FOR THE TREATMENT OF NEOPLASTIC DISEASES, RETINOPATHY, MACULAR DEGENERATION ASSOCIATED WITH AGE |