abstract |
REFERS TO 1H-QUINOXALIN-2-ONA COMPOUNDS SUBSTITUTED FOR FORMULA I WHERE R1, R2, R3, R4 ARE RADICAL ALIPHATIC, CYCLOALIPHATIC LINKED THROUGH ETER, H, HALOGEN, HYDROXYL; A IS (CH2) (n + 2), (CH2) n-CH = CH, (CH2) nCOO, (CH2) CONH, (CH2) (n + 1) NR1 ', AMONG OTHERS; n IS 0-3; p IS 0-1; r IS 0-2; X IS X1, X3, AMONG OTHERS; R1 'IS H, RADICAL ALIPHATIC, CYCLOALIPHATIC, ARYL, HETEROARYL; R2 'IS RADICAL ALIPHATIC, CYCLOALIPHATIC, ARYL, HETEROARYL; R3 'IS RADICAL ALIPHATIC, CYCLOALIPHATIC, ARYL, HETEROARYL; R4 'IS H, ARYL, HETEROARYL. PREFERRED COMPOUNDS ARE [3 '- (N, N-DIMETHYLAMINOMETHYL) -4'-HYDROXY-4' - (m-METOXYPHENYL) -CYCLOHEXYL) 6,7-DIMETHYL-3-OXO-3,4-DIHYDROQUINOXALIN- ACID AMIDE- 2-CARBOXYL; [3 '- (N, N-DIMETHYLAMINOMETHYL) -4'-HYDROXY-4' - (m-METOXYPHENYL) -CYCLOHEXYL) 6,7-DICHLORO-3-OXO-3,4-DIHYDROQUINOXALIN-2-CARBOXYL ACID AMIDE ; AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION OF 4-ARYL CYCLOHEXANE AND 4-HETEROARYL CYCLOHEXANE COMPOUNDS SUCH AS 4-HYDROXY-4- (3'-METOXYPHENIL) CYCLOHEXAN-1-ONA; 4-AMINO-4- (3'-METHOXYPHENYL) CYCLOHEXANE-1-OL, AMONG OTHERS. THE COMPOUNDS MAY BE USEFUL TO TREAT PAIN, CHRONIC PAIN, NEUROPATHIC, NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER, PARKINSON, HUNTINGTON, APOPLEJIA, BRAIN ISCHEMIA, EPILEPSIA, SCHIZOPHRENIA |