abstract |
REFERS TO FUSED BICYCLE HETEROARYL COMPOUNDS REPLACED WITH FORMULA I HETEROARYL, WHERE Z1 IS N, CR1; Z2 IS N, CR2; Z3 IS N, CR3; Z4 IS N, CR4; Z5 IS N, C; Z6 IS N, C PROVIDED THAT NO MORE THAN TWO Z1-Z6 ARE N; R1-R4 ARE H, HALOGEN, HYDROXY, NITRO, CYANE, AMINE, AMONG OTHERS, ALKYL, ALCOXY, CYCLOALKYL, ALKENYL, AMONG OTHERS; R5 IS H, HALOGEN, CYANE, HALOALKYL OR R5 REPRESENTS ALKYL, CYCLOALKYL, ARYL, ARYLALKYL, HETEROARYL, AMONG OTHERS; Q IS -C (R6) (R7), -N (ALKYL) -, OR, ON THE CONDITION THAT Q IS NOT OR WHEN X2 IS N; R6 AND R7 IS H, F, ALKYL; Y IS N, C, -CH-, -CH2-; W IS ARYLUS, HETEROARYL. PREFERRED COMPOUNDS ARE 6-CHLORO-2 - [(2-PHENYL-1H-IMIDAZOL-1-IL) METHYL] -3-PROPYLIMIDAZO [1,2-a] PYRIDINE, 6-CHLORINE-2 - {[2- (3 -FLUOROPHENYL) -1H-IMIDAZOL-1-IL] METHYL} IMIDAZO [1,2-a] PYRIDINE, 6-CHLORO-2 - {[2- (3-CHLOROPHENYL) -1H-IMIDAZOL-1-IL] METHYL} IMIDAZO [1,2-a] PYRIDINE, AMONG OTHERS. Also relates to compounds of bicyclic heteroaryl AS imidazopyridine, imidazopyrazines, imidazopyridazines, imidazopyrimidines E imidazothiazoles substituted heteroaryl and more specifically with compounds that bind to high selectivity and high affinity PLACES Benzodiazepine OF GABAA SUITABLE FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |