abstract |
REFERS TO INDEOL DERIVATIVES OF FORMULA I WHERE R1 IS SO (0-2) -A, COA, (CH2) (0-1) -A; A IS ARYL, HETEROARYL OPTIONALLY SUBSTITUTED WITH HYDROXYL, CYANE, ALKYL, ALCOXYL, THIOALKYL, AMONG OTHERS; R2 IS H, C1-C6 ALKYL, C1-C6 ALCOXYL, C1-C6 THIOALKYL; R3 IS H, C1-C6 ALKYL, R4 IS H, HALOGEN, C1-C6 ALKYL, C1-C6 ALKYL, C1-C6 THIOALKYL, HALOALKYL, CYANE, ALKYLCARBONYL; ONE OF R5, R6, R7 IS A GROUP b; W IS CH, N; R8, R9, R10 ARE H, C1-C10 ALKYL; R8 AND R9 ARE C3-C4 ALKYLENE. PREFERRED COMPOUNDS 3-BENZENOSULFONIL-7-PIPERAZIN-1-IL-1H-INDOL, 3-BENZENOSULFONIL-5-PIPERAIN-1-IL-1H-INDOL, 3-BENZENOSULFONIL-7-PIPERIDIN-4-IL-1H-INDOL , 3-BENZENOSULFONYL-1-METHYL-7-PIPERAZIN-1-IL-1H-INDOL, 3-BENZENOSULFONIL-7- (4-METHYL-PIPERAZIN-1-IL) -1H-INDOL, AMONG OTHERS. THE COMPOUNDS HAVE AFFINITY FOR THE 5-HYDROXITRIPTAMINE 5-HT6 RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF PARKINSON, ANXIETY, DEPRESSION, PSYCHOSIS, EPILEPSY, MIGRANE, SLEEP DISORDER |