abstract |
REFERS TO ARYLSULPHONAMIDES OF FORMULA I; WHERE R2 AND R3 ARE H, OH, HALOGEN, NITRO, CYANE, C1-C6 ALKYL, C1-C6 ALCOXY, COOR5, CONR6R7; R5, R6, R7 ARE H, C1-C6 ALKYL OPTIONALLY SUBSTITUTED WITH OH, HALOGEN, CYANE, AMONG OTHERS; A IS HETEROARYL; R1 IS ARYL, HETEROARYL, HETEROCYCLYL; R8, R9, R10 ARE H, C1-C6 ALKYL OR R9 AND R10 TOGETHER WITH N FORM A HETERO CYCLE OPTIONALLY SUBSTITUTED WITH C1-C4 ALKYL, R11 AND R12 ARE TRIFLUOROMETHYL, C1-C6 ALKYL, OH, C1-C6 ALKYL; R13 IS C1-C6 ALKYL, C6-C10 ARYL OPTIONALLY SUBSTITUTED WITH HALOGEN, AMINO, HYDROXY, C1-C4 ALCOXY, C1-C4 ALKYL; R4 IS C1-C6 ALKYL OPTIONALLY SUBSTITUTED WITH AMINE, HYDROXY, HALOGEN, C1-C6 ALCOXY; X IS O, S; PREFERRED COMPOUNDS ARE 3-FLUORO-2,2-DIMETHYL-N- {3 - [({4- [5- (2-PYRIDINYL) -1,2,4-OXADIAZOL-3-IL] PHENYL} SULFONIL) AMINO] PHENYL} PROPIONAMIDE; N- (3 - {[(4- {5- [3- (DIMETHYLAMINO) PHENYL] -1,2,4-OXADIAZOL-3-IL} PHENYL) SULFONYL] AMINO} PHENYL) -1-METHYL CYCLOPROPANE-CARBOXAMIDE; 1-METHYL-N- {3 - [({4- [5- (2-PYRIDINYL) -1,2,4-OXADIAZOL-3-IL] PHENYL} SULFONIL) AMINO [PHENYL} CYCLOPROPANOCARBOXAMIDE, AMONG OTHERS. THE COMPOUNDS HAVE ANTIVIRAL ACTIVITY AND MAY BE USEFUL FOR THE TREATMENT OF HCMV INFECTIONS IN PATIENTS WITH AIDS (RETINITIS, PNEUMONITIS, GASTROINTESTINAL INFECTIONS); CYTOMEGALOVIRUS (HCMV) INFECTIONS IN PATIENTS WITH BONE MARROW TRANSPLANTATION, HCMV INFECTIONS |