| abstract |
REFERS TO SUBSTITUTED DIHYDROPYRIMIDINE CYANE COMPOUNDS OF FORMULA I WHERE R1 IS H, ALKYL, CYCLOALKYL: R2 AND R3 ARE H, ALKYL, ARYL, HETEROARYL, ARYLALKYL, CYCLOALKYL, BETWEEN OTHERS; R2 AND R3 TOGETHER FORM A HETEROCYCLIC, CARBOCYCLIC RING; R4 IS ALKYL, ARYLALKYL, CYCLOALKYLALKYL, AMONG OTHERS; R5 AND R6 ARE H, ALKYL, CYCLOALKYL, AMONG OTHERS; Z IS O, S, NR8; R8 IS H, CN, SULFONAMIDE, AMONG OTHERS. PREFERRED COMPOUNDS ARE 1-ETHYL ACID ESTER OF 5-CYANE-3,6-DIHYDRO-4-METHYL-6- (3-NITROPHENYL) -2-THIOXO-1- (2H) -PYRIMIDINECARBOXYL, 1-ETHYL ACID ESTER OF 5 -CIANE-3,6-DIHYDRO-4-METHYL-6- (3-NITROPHENYL) -2-OXO-1- (2H) -PYRIMIDINE CARBOXYL, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THE MENTIONED COMPOUNDS INDUCE MYTHOTIC INTERRUPTION AND ARE USEFUL AS ANTI-CANCER AGENTS |