abstract |
REFERS TO BENZOYL COMPOUNDS OF FORMULA I WHERE X IS N, CH; R1 IS H, HALOGEN, ALCOXYL, ALKYL, AMONG OTHERS; R2 IS H, HETEROCYCLYL, ALKYL-ALKENE, ALKINE, AMONG OTHERS; R3 IS H, HETEROCYCLYL, ALKYL, AMONG OTHERS; R2 AND R3 TOGETHER FORM A 4-6-MEMBER HETEROCYCLIC RING; R4 IS HALOGEN. PREFERRED COMPOUNDS ARE (2-CHLORO-PHENYL) -4 [- (2,4-DIFLUORO-PHENYLAMINE) -PHENYL] -METHANONE, [4 (2,4-DIFLUORO-PHENYLAMINE) -PHENYL) -4 (2-METOXY- PHENYL) -METHANONE, AMONG OTHERS. IT ALSO REFERS TO A PROCESS FOR THE PREPARATION AND INTERMEDIATE COMPOUNDS. THE MENTIONED COMPOUNDS ARE INHIBITORS OF MAP KINASES AND ARE USEFUL FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |