| abstract |
REFERS TO QUINAZOLINES OF FORMULA I WHERE R1 IS H, AMINO, C1-C6 ALKYL, C1-C6 ALKENYL, AMONG OTHERS; W IS O, S, = N-R 'WHERE R' IS C1-C6 ALKYL, HYDROXYL, CYANE; X1, X2, X3 ARE N, -C-R6- WHERE R6 IS H, C1-C6 ALKYL, AMINO, AMONG OTHERS; Y IS O, S, NH, -N-C1-C6 ALKYL, AMONG OTHERS; Z IS S, -NR7- WHERE R7 IS H, C1-C6 ALKYL, AMONG OTHERS; A IS SINGLE CYCLE OF 5-6 MEMBERS, BICYCLE OF 5-6 MEMBERS, m IS 0-7; Z1 IS -CR8R9 WHERE R8 AND R9 ARE H, C1-C6 ALKYL, AMONG OTHERS; R2 IS A RING OF 5-6 MEMBERS HETEROCYCLIC AMONG OTHERS. PREFERRED COMPOUNDS BENCILAMIDE OF 3-BENZYL-2,4-DIOXO-1,2,3,4-TETRAHIDOQUINAZOLINE-6-CARBOXYL ACID, - (4-PYRIDYLMETHYL) AMIDE OF 3-BENZYL-2,4-DIOXO-1 ACID , 2,3,4-TETRAHIDOQUINAZOLINA-6-CARBOXILICO, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. THE MENTIONED COMPOUNDS ARE INHIBITORS OF MMP-13 AND ARE USEFUL FOR THE TREATMENT OF ARTHRITIS, OSTEOPOROSIS |