abstract |
REFERRED TO PIPERIDINE DERIVATIVES OF FORMULA I WHERE X IS -CH2-, -CH2-CH2-, CHR9-, -C (O) -, AMONG OTHERS; R1 IS PHENYL WITH R10, HETEROARYL, NAPHTHYL WITH R10, R11; R2 IS R1, FLUORENYL WITH R10, R11, C1-C10 ALKYL, AMONG OTHERS; R3 IS R1, FLUORENYL WITH R10, C1-C6 ALKYL, C2-C6 ALKYL, C3-C6 CYCLOALKYL, AMONG OTHERS; R4 IS R5, CH, OH, OR9, F, AMONG OTHERS; R5 IS H, C1-C6 ALKYL, C1-C6 HYDROXYALKYL, C2-C6 ALCOXYALKYL, AMONG OTHERS; R6 IS R4; R7 IS R5; R8 IS H, C1-C6 ALKYL, C2-C6 ALKYL, AMONG OTHERS; R9 IS C1-C6 ALKYL, C3-C6 CYCLOALKYL, AMONG OTHERS; R10 IS C1-C6 ALKYL, C1-C6 HYDROXYALKYL, AMONG OTHERS. A PREFERRED COMPOUND IS (2,6-DIMETHYL-PHENYL) - (4-DIPHENYLAMINE-4'-METHYL-1- [1,4 '] BIPIPERIDINYL-1'-IL) -METHANONE. IT ALSO REFERS TO A PROCESS FOR THE PREPARATION AND A PHARMACEUTICAL COMPOSITION. COMPOUNDS DERIVED FROM PIPERIDINE ARE INHIBITORS OF CCR5 AND ARE USEFUL FOR THE TREATMENT OF INFLAMMATORY DISEASES |