| abstract |
REFERS TO SULFONAMIDE LACTAMA COMPOUNDS OF FORMULA I WHERE X IS - (CH2) m- OPTIONALLY SUBSTITUTED WITH OXO, ALKYL, ARIL; m IS 1-3; R1 IS ALKYL, ALKENYL, ALKINYL, CYCLOALKYL, ARYL, CYCLOHETEROALKYL, HETEROARYL, CYCLOHETEROALKYL, R2 AND R3 ARE H, ALKYL, ALKENYL, ALKINYL, CYCLOALKYL, CYCLONE, ARYL; R4, R4a, R5, R5a ARE H, ALKYL, ALKENYL, ALKYNYL, CYCLOALKYL, AYL, HETEROARYL, CYCLOHETEROARIL, HYDROXY, ALCOXY, CORa, NRa-SO2Rb, R6 AND R6a, CYCLOALKYL, ARYL, HETEROARYL, ALKYL, ALKYL HETEROARYL, CYCLOHETEROARYL; R7 AND R8 ARE (CH2) n-H; n IS 1-4, OR TOGETHER WITH N FORMING CYCLOHETEROALKYL; Ra AND Rb ARE H, ALKYL, ALKENYL, ALKINYL, ARYL, HETEROARYL, AMONG OTHERS; EXCEPT FORMULA X COMPOUNDS, R1a IS ALKYL, ARYL, ALKYL, ALKENYL, AMONG OTHERS; R7a IS RENT, R8a IS A GROUP a; p IS 1-3; W AND W * ARE CH, N; IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION THAT ALSO INCLUDES STREPTOKINASE, RELEPLASE, ACTIVASE, LANOTEPLASE, UROCINASE, PROUROCINASE, WARFARIN, CLOPIDOGREL, ASPIRIN, THYCLAMOPIDINE, KYPETHYLOSTABANE, PYPETHYLETROBAN. THE COMPOUNDS ARE INHIBITORS OF SERINE PROTEASE OF ACTIVATED COAGULATION OR FACTOR Xa, ACTION AS ANTICOAGULANTS AND MAY BE USEFUL FOR THE TREATMENT OF CARDIOVASCULAR DISEASES ASSOCIATED WITH ARTERIAL THROMBOSIS, BRAIN VASCULAR DISEASES |