| abstract |
REFERS TO DIARY PEPTIDES OF FORMULA I WHERE X AND Y ARE ALKYL, ALKYL-ARYL, HETEROALKYL, HETEROARYL, ARYL-HETEROARYL, AMONG OTHERS; X11 IS ALKYL, ALKENYL, ALKINYL, CYCLOALKYL, CYCLOALKYL-ALKYL, AMONG OTHERS; X12 IS OH, ALCOXY, ARYLOXY, THIO, ALKYLTIO, ARYLTIO, AMONG OTHERS; W IS C = O, C = S, SO2 AND MAY BE PRESENT OR ABSENT; Q IS CH, N, P, AMONG OTHERS. WHEN Q IS ABSENT M IS ABSENT AND IS DIRECTLY LINKED TO X; A IS O, CH2, (CHR) p, (CHR-CHR ') p, AMONG OTHERS; U IS O, N, CH; E IS CH, N, CR; G IS (CH2) p, (CHR) p, AMONG OTHERS; J IS (CH2) p, (CHR) p AMONG OTHERS; L IS CH, CR, O, S, NR, AMONG OTHERS; M IS O, NR, S, SO2, AMONG OTHERS; p ES 0-6; R AND R 'ARE H, C1-C10 ALKYL, C2-C10 ALKENYL, C3-C8 CYCLOALKYL, AMONG OTHERS; P1a, P1b, P1, P3 ARE H, C1-C10 ALKYL, C2-C10 ALKYL, AMONG OTHERS; R '' IS OH, ALCOXY, ARYLOXY; Z IS O, NH, AMONG OTHERS; AR1 AND AR2 ARE PHENYL, 2-PYRIDYL, 3-PYRIDYL, 4-PYRIDYL, AMONG OTHERS; R1 IS H, HALOGEN, CYANE, NITRO, CF3, AMONG OTHERS; P4 IS H, ALKYL; R2 IS H, CYANE, CF3. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. DIARYLIC PEPTIDE COMPOUNDS ARE INHIBITORS OF THE HEPATITS C VIRUS SERINE PROTEASE NS3 / NS4 |