| abstract |
REFERS TO A METHOD OF PREVENTION OF THE OCCURRENCE OF HEADACHES AND MIGRANES THAT INCLUDES A COMPOUND OF FORMULA I WHERE R1 AND R2 ARE H, OH, CN, CH2CN, 2-CF3, CH2CF3, CH2CHF2, HC = CF2, (CH2 ) 2CF3, ETHENYL, 2-PROPENYL, OSO2CH3, OSO2CF3, COR, O (CH2) xCF3, CONH2, SOxCH3, AMONG OTHERS; x IS 0-2; R3 IS H, CF3, CH2CF3, C1-C8 ALKYL, C3-C8 CYCLOALKYL, C4-C9-METHYL CYCLOALKYL, C2-C8 ALKENYL, C2-C8 ALKYNYL, (CH2) m-R5; m IS 1-8; R5 IS CN, CF3, CH2CF3, C1-C8 ALKYL, C3-C8 CYCLOALKYL, 2-THIOPHENYL, NR6CONR6R7; R6 AND R7 ARE H, C1-C8 ALKYL, C3-C8 CYCLOALKYL, C2-C8 ALKYL; n IS 1-2; R4 AND R ARE H, CF3, CH2CF3, C1-C8 ALKYL, C3-C8 CYCLOALKYL, C4-C9-METHYL CYCLOALKYL; A PREFERRED COMPOUND BEING S - (-) - 3- [3- (METHYLSULFONYL) PHENYL] -1-PROPYL-PIPERIDINE; USING FROM 0.5mg TO 2mg; ALSO REFERS TO USE WITH AN ANALGESIC, ANTI-INFLAMMATORY, ERGOTAMINE, TRIPTAN |