| abstract |
REFERS TO FORMULA I CYCLOALKYL PHENYL ALCANOIC ACID COMPOUNDS WHERE RING A IS A 4-8 MEMBER MONO-CYCLE RING, 7-12-MEMBER BICYCLE RING; A1 IS A 5-9 MEMBER MONOCYCLE RING, 7-14 MEMBER POLYCYCLE HETERO CYCLE, NR5-C (= Y1) -NR8R7, NR5C (Y2) (= NR7); WHEN Z1 IS CO, SO2, THE A1-Z2 LINK INCLUDES PYRIDINE, IMIDAZOLE, THIAZOLE, OXAZOLE, BENZIMIDAZOLE, IMIDAZOPYRIDINE; Y1 IS NR2, O, S; R2 IS H, ALKYL, ARYL, OH, ALCOXY; R7 AND R8 ARE H, ALKYL, ARALKYL, AMINO, ALKYLAMINE; NR7 AND R8 FORM A SINGLE CYCLE, BICYCLE RING; R5, Rm, Rp, Rk, Rf ARE H, ALKYL; A IS NR5C (Y) = NR '; Y2 IS RENT, CYCLOALKYL, CYCLOALKYL, BETWEEN GOLD; Z1 IS CH2, O, NH, NRk, AMONG OTHERS; Z2 IS A C2-C5 LINK; Z1-Z2 ALSO CONTAINS CARBOXAMIDE, SULFONE, LINKED TO RING A IN POSITION FOR OR TARGET IN RELATION TO X1; n IS 0-1; Rc IS H, ALKYL, HALOGEN, OH, AMONG OTHERS; X1 IS O, CO, SO2, NRm, (CHRp) q; Rp IS H, ALKYL, ALCOXY, OH; q IS 0-1; X2 IS CHRe, CO, SO2, NRf, S. X or Y IS CRg, N; Rg IS H, ALKYL, HALOALKYL, FLUORINE, AMONG OTHERS, X-X2-Y CONTAINS ACILO, ALKYL, AMINO, AMONG OTHERS; Rb ES X3-Rh; X3 IS O, S, NRj; Rj AND Rh SON H, RENT, ACILO, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE 2- [4- [3- (2-PYRIDINYLAMINE) PROPOXI] PHENYL] CYCLOPROPANE-ACETIC ACID, AMONG OTHERS. THE COMPOUNDS ARE ANTAGONISTS OF INTEGRIN OVß3 AND MAY BE USEFUL FOR THE TREATMENT OF TUMOR METASTASIS, TUMOR GROWTH, OSTEOPOROSIS, PAGET'S DISEASE, RETINOPATHY, MACULAR DEGENERATION |