abstract |
REFERS TO 1-AMINOBUTANE-3-OL DERIVATIVES SUBSTITUTED FOR FORMULA I WHERE R1 AND R2 ARE C1-C6 ALKYL; R1 AND R2 TOGETHER REPRESENT A CYCLE (CH2) 2-9 SUBSTITUTED WITH C1-C8 ALKYL, STRAIGHT OR BRANCHED CHAIN; R3 AND R4 ARE C1-C6 ALKYL, C3-C6 CYCLOALKYL, PHENYL; R3 AND R4 TOGETHER FORM A CYCLE AND REPRESENT (CH2) 3-6 OR CH2CH2OCH2CH2; R5 IS C1-C10 ALKYL, C3-C9 CYCLOALKYL, ARYL, HETEROARYL, SUBSTITUTED WITH F, Cl, Br, I, OR18, SR18, AMONG OTHERS; R18 IS H, C1-C10 ALKYL, ARYL, AMONG OTHERS; R6 IS H, ARYL, HETEROARYL; R7 IS HALOGEN, CF3, C1-C6 ALKYL. PREFERRED COMPOUNDS ARE 2-BENZYL-1- (2,4-DICHLOROBENZYL) -6-DIMETHYLAMINOMETHYL-CYCLOHEXANOL, 2-BENZYL-1- (3-CHLOROBENZYL) -6-DIMETHYLAMINOMETHYL-CYCLOHEXANOL, 2-BENZYL-6-DIMETHYLIN-1-BENZYL-6-DIMETHYL - (2,5-DIMETHYLBENZYL) -CYCLOHEXANOL, AMONG OTHERS. THE MENTIONED COMPOUNDS ARE AGONISTS OF GABAPENTIN AND ARE USEFUL FOR THE TREATMENT OF MIGRANAS, HYPERALGESIA, INFLAMMATORY PAINS |