abstract |
REFERS TO BENZOIC ACID DERIVATIVES SUBSTITUTED FROM FORMULA I WHERE R1, R2 ARE H, ALKYL; A IS C (R5R6); n IS 1-3; A IS O; B IS C (R3R4), O, S (O) m, N-ALKYL; IF A IS O, B IS C (R3R4); m IS 0-2; X IS CR7 ', N; R3, R4, R5, R6 ARE H, ALKYL, R7 AND R7 'ARE H, ALKYL, ALKENYL, ALCOXY, ALCOXYALKYL, OR TOGETHER ARE (CH2) p; p ES 2-6; IF X IS N, R7 IS ALKYL, ALCOXYALKYL; Z IS COO, OCO, H2C-CH2, AMONG OTHERS; IF Z IS OCH2, SCH2, X IS CR7 '; IF Z IS C = C, X IS CR7 'AND R7 IS PHENOXY; Ar IS PHENYL, HETEROARYL, R8 IS H, ALKYLOBENZYL. THE PREFERRED COMPOUNDS ARE (RS) - (E) -4- [3- (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHIDRONAPHTHALEN-2-IL) -OCT-1-ENYL] BENZOIC ACID ; (RS) -4- [2- (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-IL) HEPTANOYLOXY] BENZOIC ACID, (RS) - (E) - 4- [3- (4,4-DIMETHYL-THIOCHROMAN-6-IL) -OCT-1-ENYL] -BENZOIC, AMONG OTHERS. COMPOUNDS I ARE AGONISTS OF THE RETINOIC ACID GAMMA RECEPTOR AND MAY BE USEFUL FOR THE TREATMENT OF EMPHYSEMA, ASSOCIATED PULMONARY DISEASES |