| abstract |
REFERS TO A METHOD TO PREPARE COMPOSITIONS THAT INCLUDE: a) PREPARING A HOMOGENEOUS SOLUTION OR DISPERSION OF A LIQUID AND A COMPOUND SUCH AS OSELTAMIVIR or (5- [7- [2- (5-METHYL-2-PHENYL-OXAZOL-4 -IL) -ETOXY] -BENZOTHIOPHEN-4-METHYL] -2,4-THIAZOLIDINDIONA or A LIPASE INHIBITOR SUCH AS ORLISTAT; EXCIPIENTS CONTAINING A COATING MATERIAL OR FORMER OF A VITREA PASTE SUCH AS POLYOL (MALTHODALTYEXTRINE, MALTHALTHODYXTRINE , BETWEEN OTHERS), RUBBER OR POLYMER (POLYENTIELENGLYCOL, STARCH, CELLULOSE, POVIDONE, BETWEEN OTHERS), TENSIOACTIVE (SODIUM LAURYLSULFATE, SODIUM DOCUSATE, SODIUM CASEINATE, FATTY ACID OR EXTROSION SALTS); OR HOMOGENEOUS DISPERSION THAT DEVELOPS A GREATER VOLUME AND SURFACE BY MEANS OF A CHANGE (DECREASE) OF THE PRESSURE BETWEEN 30 AND 150 TORR WITHOUT REACHING THE BOILING; c) DRYING OR COOLING. THE COMPOSITION IS CHARACTERIZED BY HAVING A RESIDUAL SOLVENT LEVEL BETWEEN 0.1% p / p AND 10% p / p; APPARENT DENSITY (PER SPILL) BETWEEN 0.1g / cm3 AND 0.9g / cm3; PARTICLE SIZE BETWEEN 50µm AND 600µm |